MORPHOLOGICAL FEATURES OF THE ENDOMETRIUM TRANSFORMATION IN RECURRENT MISCARRIAGE

The problems of pathological diagnosis recurrent miscarriage are relevant in modern reproductive medicine. One the important molecular markers endometrium is progesterone-induced blocking factor, which induced by progesterone under influence activated lymphocytes and has an immunomodulatory effect on implantation characteristics endometrium. In process trophoblast invasion, a special role also played stromal cell factor molecules synthesized endometrial cells, as mechanism that potentiates susceptibility to onset development pregnancy, invasion embryogenesis general. purpose study was histological immunohistochemical features transformation miscarriage. It were studied 100 samples case non-developing pregnancy at period 5-8 weeks, 85 habitual 15 interrupted surgically request woman. presence 2 pregnancies verified 57 cases (67,1%), 3 28 (32,9%). A examination abortion material stained with hematoxylin eosin performed verify morphological Immunohistochemical included detection estrogen receptors, (SDF1), (PIBF). results studies showed complete group patients miscarriage, there violation receptor profile. decrease PIBF expression glands component SDF1 compact layer reflection immunological imbalance unified algorithm, taking into account basic indicators processes assessment its profile diagnostically significant factors, makes it possible pathology level justify need for using pathogenetically substantiated therapy